Towards a new era of personalised ITI treatment
In patients with severe haemophilia it is known that the incidence of inhibitor is around 30%, the potential impact of the type of factor VIII (FVIII) product administered still being disputed.1...
Aprotinin to Reduce Bleeding in Cardiac Surgery - An Update
Patients undergoing cardiac surgery with cardiopulmonary bypass (CPB) are at risk for excessive intra- and postoperative bleeding as a result of many factors, including CPB-related alterations in...
Embracing the Challenge of Advancing Age in Managing Hemophilia: New Clinical Challenges
Thanks to improvements in care, life expectancy for people with hemophilia is longer than it has ever been, such that many patients live to ages similar to those expected for the non-hemophilic...
Is salvage therapy possible in patients with diffuse large B-cell lymphoma (DLBCL) after failure of standard second-line regimens?
The following is an overview of a satellite symposium held on 29 April 2014 during the BSH Annual Scientific Meeting in Birmingham. The symposium was organised and funded by CTI Life Sciences and...
Perioperative bleeding: haemostatic therapy in cardiovascular surgery and obstetric emergencies
It is currently an exciting time for those interested in the management of perioperative bleeding; recent advances in understanding and approach herald improvements in the approach to perioperative...
Building on the pillars of traumatic coagulopathy: advancing the management of trauma-related bleeding
The clinical management of trauma-related bleeding is rapidly evolving. While mechanical bleeding can be addressed through surgical measures, the patient’s coagulopathic state should also be...
The challenge of rapid and targeted treatment of acute bleeding
Addressing the current challenges involved in the treatment of acute and life-threatening bleeding is key for improving patient outcomes. The timing and nature of the haemostatic interventions are...
The current role of rasburicase in the management of hyperuricaemia as a result of chemotherapy for leukaemia or lymphoma
In humans, uric acid is the final step in the catabolic pathway of purines. The acute increase in plasma levels of uric acid subsequent to the lysis of large numbers of malignant cells during...
Dabigatran etexilate and stroke prevention
Laura Green1 and Hannah Cohen2 1Department of Haematology, Barts and the London Hospital NHS Trust & NHS Blood & Transplant, London, UK; 2Department of Haematology, University College London...
The place of oral anticoagulants in elective total hip replacement and total knee replacement surgery – a practical guide
Surgery for elective total hip (THR) and knee (TKR) replacement is associated with a very high risk of venous thrombosis Some orthopaedic surgeons have been overcautious in their use of prophylaxis,...