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In humans, uric acid is the final step in the catabolic pathway of purines. The acute increase in plasma levels of uric acid subsequent to the lysis of large numbers of malignant cells during...
Das hereditäre Angioödem (HAE) ist eine seltene genetische Erkrankung, die auf einer verringerten Konzentration oder Aktivität des C1-Esterase-Inhibitors (Typ I und II) beruht. Dermatologen,...
Immune mediated inflammatory diseases share common inflammatory pathways and encompass diverse disorders. Immune dysregulation may affect any organ system causing significant morbidity, impaired...
The long-term survival of endosseous intra-oral implants has become a public health issue in recent years inasmuch as tens of millions of patients now have one or more of these implants. To ensure...
Introduction There has been a rapid expansion in the use of biopharmaceuticals over the last decade, with indications now ranging from autoimmune disease such as rheumatoid arthritis to malignant...
Alzheimer’s disease (AD) is associated with progressive deterioration of cognitive and functional abilities (Fig. 1). To date, there is no cure and no validated disease-modifying treatment....
Laura Green1 and Hannah Cohen2 1Department of Haematology, Barts and the London Hospital NHS Trust & NHS Blood & Transplant, London, UK; 2Department of Haematology, University College London...
Bei vielen Patienten mit mittelschwerer und schwerer Plaque-Psoriasis haben sich Biologika als wirkungsvolle Therapie gezeigt. Da es sich um eine chronische Erkrankung handelt, erfolgt die Behandlung...
The expectations of patients considering the replacement of lost oral structures or missing teeth focus primarily on the treatment outcome. The objective is to restore function at a high level and to...
More than 60 genetic disorders have been identified that may present with psychosis, including several inborn errors of metabolism (IEM). One such IEM, Niemann-Pick disease type C (NP-C), is a rare...