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Neurology

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Sleep disturbance and epilepsy: an important and complex relationship not to be ignored

Sleep disturbance and epilepsy: an important and complex relationship not to be ignored

A restful night’s sleep is a key element in maintaining health and wellbeing, but perhaps less well appreciated is the complex relationship between sleep and diseases such as epilepsy: sleep...

Optimising the use of perampanel in clinical practice

Optimising the use of perampanel in clinical practice

Perampanel is a broad-spectrum antiepileptic drug (AED) with a novel mechanism of action. It is effective as adjunctive therapy to help control both focal-onset seizures and primary generalised...

Eslicarbazepine acetate use in clinical practice: an overview of the evidence

Eslicarbazepine acetate use in clinical practice: an overview of the evidence

Epilepsy affects more than 50 million people worldwide – impacting at least six million in Europe. The condition is generally manageable with pharmacotherapy, with which many people with epilepsy...

Appropriate positioning of eslicarbazepine acetate in the treatment pathway for people with focal-onset seizures

Appropriate positioning of eslicarbazepine acetate in the treatment pathway for people with focal-onset seizures

A group of epilepsy specialist clinicians gathered to discuss the pharmacological management of focal epilepsy and the potential role of eslicarbazepine acetate (Zebinix). The meeting was organised...

Perampanel in generalised tonic-clonic seizures

Perampanel in generalised tonic-clonic seizures

Primary generalised tonic-clonic (PGTC) seizures are the most frequent and disabling seizure type among patientswith idiopathic generalised epilepsy. Uncontrolled seizures are associated with high...

Perampanel in real-world clinical practice: What we have learned till now?

Perampanel in real-world clinical practice: What we have learned till now?

Perampanel is a long-acting novel antiepileptic drug (AED) with a unique mechanism of action targeting the AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) receptor. Perampanel’s...

Dilemmas and challenges in the management of generalised tonic-clonic seizures

Dilemmas and challenges in the management of generalised tonic-clonic seizures

Correct classification of the epilepsy type after the first generalised tonic-clonic (GTC) seizure is important for the choice of treatment. There is a high disease burden with uncontrolled GTC...

Tuberous sclerosis complex: from child to adult

Tuberous sclerosis complex: from child to adult

Tuberous sclerosis complex (TSC) is an autosomal dominant genetic disorder that can cause non-invasive hamartomatous lesions of any number and size in almost every organ, but are most commonly...

A biography of Niemann-Pick disease type C: Presented at the European Academy of Paediatric Societies, 2012

A biography of Niemann-Pick disease type C: Presented at the European Academy of Paediatric Societies, 2012

Increasing awareness of Niemann-Pick type C (NP-C) was the focus of the Actelion-sponsored satellite symposium ‘One diagnosis, three presentations, many lives: a biography of Niemann-Pick type C...

Combination of memantine and cholinesterase inhibitors in the treatment of AD

Combination of memantine and cholinesterase inhibitors in the treatment of AD

Alzheimer’s disease (AD) is associated with progressive deterioration of cognitive and functional abilities (Fig. 1). To date, there is no cure and no validated disease-modifying treatment....

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