Figure 3. Slower release of tacrolimus from Envarsus® means most of the drug is delivered at the colon where the metabolism due to CYP3A5 is lower.18 (Adapted from Mercuri A, Wu S, Stranzinger S. In vitro and in silico characterisation of tacrolimus released under biorelevant conditions. Int J Pharmaceutics 2016;515:271–80. © 2016, with permission from Elsevier)