... to the pages of Key Opinions in Medicine (KOM) KOM is a newsletter service delivered by Wiley-Blackwell to update healthcare professionals on new developments across various therapy areas.

KOM began its life with Dermatology and Hematology, but we are constantly trying to broaden our spectrum and grow. We are looking forward to interaction with our readers so please feel free to send questions and comments to us.

Latest Issues

Efficacia e tollerabilità di pantoprazolo

Circa 30 anni fa l’avvento di potenti farmaci acido-inibenti, quali gli inibitori della pompa protonica (PPI), ha permesso di avere un’arma molto più efficace degli H2-antagonisti, protagonisti incontrastati fino ad allora, nella terapia delle malattie cosiddette “acido-correlate”.

Topic: Gastroenterology issue: 2/2015

Lansoprazolo: un trattamento efficace per la compliance dei pazienti e per la prevenzione dell'ulcera

È risaputo che i farmaci anti-infiammatori non steroidei (FANS), inclusa l’aspirina, rappresentano la categoria di farmaci più utilizzati nella pratica clinica quotidiana per molteplici ragioni: il progressivo invecchiamento della popolazione del mondo occidentale con la necessità crescente di instaurare una profilassi di incidenti cerebro e cardiovascolari con aspirina a basso dosaggio, maggiore incidenza di patologie reumatologiche con esigenza di prescrivere farmaci anti-infiammatori non solo per periodi acuti di breve

Topic: Gastroenterology issue: 1/2015

Towards a new era of personalised ITI treatment

In patients with severe haemophilia it is known that the incidence of inhibitor is around 30%, the potential impact of the type of factor VIII (FVIII) product administered still being disputed. Approximately 85% of FVIII inhibitors are directed against the A2 or C2 domains of the molecule, and most of the remainder at the amino-terminal region of the A3 domain. In about 60% of patients, there are two or three major inhibitor binding sites on the FVIII molecule. Anti-C2 and -A3 antibodies prevent FVIII from interacting normally with von Willebrand factor (VWF) and/or phospholipids, and the anti-A2 and anti-A3 antibodies interfere with the formation and activity of the tenase complex, blocking a pathway to the generation of thrombin. ...

Topic: Haematology issue: 1/2015

Malignes Melanom: Neue Chancen durch die onkolytische Immuntherapie

Die Immuntherapie, die die natürliche Krebsabwehr des Immunsystems verstärkt, hat die Überlebenszeiten von Patienten mit malignem Melanom deutlich verlängert. Moderne gentechnische Verfahren machen es heute möglich, Viren in hren Eigenschaften gezielt zu verändern. Damit werden Viren zu attraktiven Kandidaten in der onkologischen Forschung.

Topic: Dermatology issue: 1/2015

Aprotinin to Reduce Bleeding in Cardiac Surgery - An Update

Bleeding and transfusion in cardiac surgery.

Patients undergoing cardiac surgery with cardiopulmonary bypass (CPB) are at risk for excessive intra- and posoperative bleeding as a result of many factors, including CPB-related alterations in the haemostatic system and exposure to long-acting antithrombotic agents.

Topic: Haematology issue: 3/2014


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