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... to the pages of Key Opinions in Medicine (KOM) KOM is a newsletter service delivered by Wiley-Blackwell to update healthcare professionals on new developments across various therapy areas.

KOM began its life with Dermatology and Hematology, but we are constantly trying to broaden our spectrum and grow. We are looking forward to interaction with our readers so please feel free to send questions and comments to us.

Latest Issues

Towards a new era of personalised ITI treatment

In patients with severe haemophilia it is known that the incidence of inhibitor is around 30%, the potential impact of the type of factor VIII (FVIII) product administered still being disputed. Approximately 85% of FVIII inhibitors are directed against the A2 or C2 domains of the molecule, and most of the remainder at the amino-terminal region of the A3 domain. In about 60% of patients, there are two or three major inhibitor binding sites on the FVIII molecule. Anti-C2 and -A3 antibodies prevent FVIII from interacting normally with von Willebrand factor (VWF) and/or phospholipids, and the anti-A2 and anti-A3 antibodies interfere with the formation and activity of the tenase complex, blocking a pathway to the generation of thrombin. ...

Topic: Haematology issue: 1/2015

Malignes Melanom: Neue Chancen durch die onkolytische Immuntherapie

Die Immuntherapie, die die natürliche Krebsabwehr des Immunsystems verstärkt, hat die Überlebenszeiten von Patienten mit malignem Melanom deutlich verlängert. Moderne gentechnische Verfahren machen es heute möglich, Viren in hren Eigenschaften gezielt zu verändern. Damit werden Viren zu attraktiven Kandidaten in der onkologischen Forschung.

Topic: Dermatology issue: 1/2015

Aprotinin to Reduce Bleeding in Cardiac Surgery - An Update

Bleeding and transfusion in cardiac surgery.

Patients undergoing cardiac surgery with cardiopulmonary bypass (CPB) are at risk for excessive intra- and posoperative bleeding as a result of many factors, including CPB-related alterations in the haemostatic system and exposure to long-acting antithrombotic agents.

Topic: Haematology issue: 3/2014

Embracing the Challenge of Advancing Age in Managing Hemophilia

Thanks to improvements in care, life expectancy for people with hemophilia is longer than it has ever been, such that many patients live to ages similar to those expected for the non-hemophilic population

However, aging presents specific challenges for people with hemophilia, especially those with inhibitors or chronic viral infection

Topic: Haematology issue: 2/2014

Quali novità in tema di FANS? Diclofenac HPbCD

Como è noto, i FANS attualmente disponibili si dividono in tradizionali e coxib capaci di inibizione selettiva nei confronti delle COX-2. La COX-2 selettività è una propietà dei FANS diversamente espressa nei modelli sperimentali e non trasferibile "tout court" nell'uomo.

Topic: Rheumatology issue: 1/2014

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